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PML is a ROS sensor activating p53 upon oxidative stress

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4 PD complications and comorbidities Recent epidemiological surveys have refined our understanding of comorbidity patterns in PD

The enzyme uses either iron or manganese as a cofactor and catalyzes the degradation or reduction of hydrogen peroxide (H2O2) to water and molecular oxygen, consequently completing the detoxification process imitated by SOD.35, 36 It is abundant in cells, where it continuously scouts for hydrogen peroxide molecules